Dr Mitchel Goldman
Journal of Drugs in Dermatology, Volume 19, Issue 11, Nov 2020

Dr. Elika Hoss M.D., Dr. Ramya Kollipara M.D., Dr. Marwan Alhaddad M.D., Dr. Monica Boen M.D., Dr. Mitchel P. Goldman M.D.

Cosmetic Laser Dermatology, San Diego, California, United States

Red Deer Umbilical Cord-Derived Stem Cell Conditioned Media Combined With Ablative Resurfacing of the Face


Laser resurfacing is the gold standard procedure for photodamage, but is not without downtime and risk. Use of periprocedural products containing stem cell conditioned media may improve results and optimize healing.


This was a prospective, randomized controlled, double-blind study, evaluating the efficacy and tolerability of red deerumbilical cord-derived stem cell conditioned media (USCCM) cream and serum pre- and post- ablative facial resurfacing.

Twenty patients with moderate to severe photodamage were randomized to receive vehicle or USCCM cream and serum pre- and post- ablative resurfacing of the face. Blinded investigators rated healing, tolerability, and efficacy, while
subjects rated post-procedure symptoms, tolerability, and satisfaction.


Both the active and vehicle pre-procedure cream were soothing, calming and easy to use by all patients. There was a trend towards decreased facial erythema and crusting in the active versus vehicle group. A greater improvement in wrinkling occurred in the active group. The majority of subjects were very satisfied with the active products. There were no serious adverse events.
Subject who received vehicle VS active products at baseline, post-procedure day 1, day 5, day 7 and day 14
Blinded investigator scoring of the Fitzpatrick-Goldman Elastosis and Wrinkling scale at screening, baseline, treatment day, and day 30


Red deer umbilical cord-derived stem cell conditioned media (USCCM) is well tolerated, safe, and efficacious for use pre- and post- facial laser resurfacing.
Additionally, USCCM may also enhance the results of ablative CO2 resurfacing. At day 30 a greater decrease in wrinkling was seen in the active group than the vehicle group and similar improvement was seen in elastosis. Subjects also reported a greater improvement in skin quality at all time points with use of the active products.