CALECIM® Professional Eye Contour Lifting Cream: A 12-week cosmetic study evaluating the effectiveness of a revolutionary skincare product for restoring the thinning skin around the eyes

Objectives

Primary Objective: To evaluate the ability of the eye cream to increase skin elasticity.
Primary Endpoint: Comparison of the skin elasticity in percent at baseline and Week 12.
Safety Objective: To evaluate the safety of the eye cream.

Inclusion Criteria

Subjects who meet all the following criteria are eligible for this study:

• Adult female or male subject 40 years of age or older at initiation visit (n=10).
• Willingness to abstain from any aesthetic or surgical procedures in the facial area for the duration of the study.
• Subjects having understood the purpose and conduct of the study and have given written informed consent.
• Subjects are willing and able to adhere to the study protocol.
• Subjects with dry skin, loss of elasticity, fine lines and overall unsatisfaction with skin quality and skin appearance around the eyes.

Exclusion Criteria

Subjects who meet any of the following criteria are not eligible for this study:

• Female subjects who are pregnant or breastfeeding at initiation visit
• History of hypersensitivity against the ingredients of the eye cream
• Presence of infectious or inflammatory lesions in the facial area
• Any dermatologic disease that might bias the evaluation facial area
• Any medical condition prohibiting the inclusion in the study according to the judgement of the investigator.

Measurements

Cutometry: The Cutometer® Dual MPA 580 (Courage+Khazaka electronic GmbH) and in particular its R2-value was used to assess the elasticity of the skin in percent.

Corneometry: Corneometer® CM 825 (Courage+Khazaka electronic GmbH) was used to assess the hydration level of the skin in percent.

Visia® Skin Analysis System: Visia® Skin Analysis System (Canfield Scientific Inc.) was used to assess skin wrinkles in percent.

Dark Circles: Dark Circles Eye scale was used to assess the degree of dark circles.

Global Aesthetic Improvement Scale (GAIS): Global Aesthetic Improvement Scale (GAIS) was used to assess overall improvement by the investigators and the subjects.

Safety Monitoring: The safety of the subjects was monitored throughout the study, from baseline beginning immediately after start of initiation of the application of the eye contour lifting cream until the final visit at week 12.

Schedule of Assessments

Visit 1: Week 1
Visit 2: Week 4 (+/- 5 days)
Visit 3: Week 8 (+/- 5 days)
Visit 4: Week 12 (+/- 5 days)

Results

• 0 subjects reported any undesirable effects.

• The mean skin elasticity increased by 2.4 points from 61.4% to 63.8%.

• Skin wrinkles measures decreased from 44.1% at baseline by 2.8%, 6.1% and 5.4%, respectively, at week 4, 8 and 12.

• Dark circles decreased from 4.8 units by 0.1, 0.8 and 0.5 units, respectively.